pentobarbital will lower the extent or outcome of artemether/lumefantrine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration with sturdy CYP3A4 inducers can result in lessened serum concentrations and lack of antimalarial efficacy
Drugs that have action therapy associated with Every single prescription. This restriction usually necessitates that particular requirements be satisfied previous to approval for your prescription.
pentobarbital increases toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. CYP3A4 inducers may well increase the metabolism of ifosfamide to its Energetic alkylating metabolites.
Comment: Barbiturates may perhaps improve adverse effects, which include respiratory depression, produced by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates boost metabolism and reduce blood concentrations of TCAs.
Estradiol valerate/dienogest really should not be made use of for a minimum of 28 times right after discontinuation with the inducer resulting from likelihood of lessened contraceptive efficacy.
Following oral or parenteral administration, barbiturates conveniently cross the placental barrier and therefore more info are dispersed all through fetal tissues with optimum concentrations located in the placenta, fetal liver, and brain; fetal blood stages approach maternal blood stages next parenteral administration
pentobarbital will lower the extent or impact of flurbiprofen by impacting hepatic enzyme CYP2C9/ten metabolism. Minor/Significance Unknown.
pentobarbital will reduce the level or result of methylprednisolone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will decrease the extent or result of docetaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unidentified.
pentobarbital will decrease the level or result of doravirine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
Contraindicated (1)pentobarbital will lower the extent or result of lorlatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
Observe Carefully (1)pentobarbital will lessen the extent or effect of glecaprevir/pibrentasvir by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
Physical exercise caution when administered to individuals with acute or Serious ache; could end in paradoxical exhilaration or vital signs could possibly be masked
pentobarbital will decrease the level or influence of ramelteon by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Mysterious.